Progressive supranuclear palsy is a rare neurodegenerative tauopathy causing postural instability, vertical gaze palsy, bradykinesia, and progressive cognitive and motor impairment.
MRI-guided brain stimulation achieved 80% response rates for treatment-resistant depression versus 60% with conventional targeting, per a JAMA Psychiatry study. Separately, Barcelona researchers developed an MRI tool to accurately identify rare neurodegenerative tauopathies PSP and CBD, while experts in Paris discussed AI's growing role in predictive psychiatry.
Quantitative and functional MRI techniques are gaining traction as biomarkers in neurodegenerative diseases. A consensus statement provides MRI endpoint recommendations for clinical trials in hereditary ataxias like SCA and Friedreich ataxia. Separately, research shows resting-state fMRI can distinguish subtypes of multiple system atrophy and may improve early diagnosis.
Arvinas announced phase 1 results for ARV-102, a PROTAC degrader that achieved more than 50% LRRK2 degradation in cerebrospinal fluid of Parkinson's patients after 28 days, with no serious adverse events reported.
Researchers at the University of Toronto have discovered that progressive supranuclear palsy has distinct molecular subtypes based on tau protein distribution, opening pathways for precision medicine approaches to treat this fatal neurodegenerative disease.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
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RECRUITING | NA |
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RECRUITING | NA |
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The CurePSP Genetics Program |
RECRUITING | |
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RECRUITING | |
| NCT06588673 |
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ACTIVE_NOT_RECRUITING | NA |
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RECRUITING | |
| NCT06501469 |
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RECRUITING | |
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NMR Based Metabolomic Study of Serum Biomarkers in Patients With Parkinson's Disease and Atypical Parkinsonian Syndrome |
RECRUITING | |
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A Study to Assess the Efficacy, Safety, and Pharmacokinetics of FNP-223 to Slow Progression of Progressive Supranuclear Palsy (PSP) |
ACTIVE_NOT_RECRUITING | PHASE2 |
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Administration of GV1001 for the Treatment of Progressive Supranuclear Palsy Who Completed Study GV1001-PSP-CL2-011 |
COMPLETED | PHASE2 |
