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Effect of G6PD Deficiency on Red Blood Cell Storage

NCT04081272 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2019-09-17

No results posted yet for this study

Summary

The proposed study will determine whether G6PD-deficient RBCs store differently than normal RBCs under standard blood banking conditions. The investigators plan to screen a large number of healthy male volunteers for G6PD deficiency in order to identify 10 G6PD deficient and 30 matched normal individuals using a blood sample obtained from a finger-stick. The identified individuals will then be asked to donate a unit of blood that will be stored for up to 42 days and various tests will be performed on these units during storage. At 6 weeks of storage a portion of the unit will be radioactively labeled and re-infused into the volunteer. Blood samples will be drawn before, during, and after the infusion to measure how well or poorly the red blood cells survive after transfusion.

Conditions

  • G6PD Deficiency

Interventions

DRUG

Sodium Chromate Cr51

Sodium Chromate Cr 51 will be used to perform a red blood cell recovered study 24 hours post-transfusion.

Sponsors & Collaborators

Principal Investigators

  • Richard O Francis, MD, PhD · Columbia University

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-11-30
Primary Completion
2017-08-31
Completion
2017-10-31
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04081272 on ClinicalTrials.gov