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Effects of Transfusion of Older Stored Red Cells

NCT01534676 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 3

Last updated 2016-10-05

Study results available
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Summary

The purpose of this study is to determine the effects of transfusion of fresh and stored blood on patients.

The investigators hope to test:

* whether a similar effect (older stored blood is associated with worse outcomes) is seen in chronically transfused patients with hemoglobinopathies. This patient population will also allow the investigators to test whether iron- chelation therapy is beneficial in this setting.
* whether washing or cryopreserving the red blood cells has any effect on this outcome.

These findings may explain the immunomodulatory effects of older stored blood in patients and will help us develop safer transfusion products for patients.

Conditions

Interventions

PROCEDURE

Transfusion

A routine medical procedure to transfuse packed red blood cells.

BIOLOGICAL

Blood

Processing of RBC for transfusion include the following: * Fresh * Stored * Washed * Frozen (Cryopreserved)

PROCEDURE

Chelation therapy

(non-experimental) A medical procedure that involves the administration of chelating agents to remove heavy metals from the body.

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • Columbia University

    lead OTHER

Principal Investigators

  • Steven Spitalnik, MD · Columbia University

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
1 Year
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-02-29
Primary Completion
2013-03-31
Completion
2013-03-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01534676 on ClinicalTrials.gov