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Triggering Ovulation at Follicle Size Smaller or Larger Than 17mm in a Modified Natural Cycle

NCT07088952 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 572

Last updated 2026-01-13

No results posted yet for this study

Summary

The rise in frozen embryo transfer (FET) cycles within assisted reproductive technology (ART) has sparked the need to refine endometrial preparation protocols. The switch from hormone replacement cycles (HRT) to natural cycles, poses scheduling challenges onto laboratories, doctors and patients. The modified natural cycle (mNC), offering more precision for scheduling, shows promise but lacks comprehensive data on the potential flexibility of triggering criteria that may allow to control timing in a wider range.

This prospective randomized study seeks to address this knowledge gap by evaluating the non-inferiority of triggering ovulation in mNC with follicle diameters of 13-16.9mm compared to the conventional 17-22mm.

The study aims to enhance the understanding of the impact of follicle size at ovulation in reproductive outcomes, optimize FET treatments providing a more flexible mNC protocol, and improve patient care in ART clinics.

Conditions

  • Embryo Transfer

Interventions

PROCEDURE

Trigger at smaller folicular size

Trigger indicated at folicular diameter smaller than standard clinical practice, from 13mm to 16.9mm

Sponsors & Collaborators

  • Vida Recoletas Sevilla

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-10-22
Primary Completion
2027-07-30
Completion
2028-05-30

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07088952 on ClinicalTrials.gov