MedTrace Logo

Evaluation of Efficacy of Lycium Barbarum Polysaccharide in People With Subthreshold Depression

NCT04032795 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 172

Last updated 2021-11-19

No results posted yet for this study

Summary

Lycium barbarum, a traditional Chinese herbal medicine, is a commonly used herb in the traditional Chinese pharmacopoeia . Its main active ingredient, lycium barbarum polysaccharide (LBP), is reported to have neuroprotective effects. Animal studies suggested that LBP has neuroprotective effect on optic ganglion cells. In animal models of depression, LBP can improve depressive symptom by improving synaptic plasticity. However, its clinical effect remains to be studied. We will conduct a 6-week double-blind, randomized, placebo-con-trolled trial in people with subthreshold depression.The purpose of this clinical trial is to investigate the efficacy of LBP in people with subthreshold depression.

Conditions

  • Subthreshold Depression
  • Depressive Symptoms
  • Anxious Symptoms

Interventions

DIETARY_SUPPLEMENT

Lycium barbarum polysaccharide

Experimental group takes Lycium barbarum polysaccharide (LBP) tablet (300mg/day)for 6 weeks

DIETARY_SUPPLEMENT

Placebo

Placebo-controlled group take he placebo capsules that are identical in shape, color, and taste to LBP tablet.

Sponsors & Collaborators

  • Fifth Affiliated Hospital of Guangzhou Medical University

    collaborator OTHER

  • Guangzhou Psychiatric Hospital

    lead OTHER_GOV

Principal Investigators

  • Kwok-Fai So, PhD · Guangzhou Medical University

  • Kangguang Lin, MD,PhD · Guangzhou Brain Hospital (Guangzhou Huiai Hospital);The fifth affiliated hospital of Guangzhou Medical University

  • Xuan Mo, MD · Fifth Affiliated Hospital of Guangzhou Medical University

  • Guiyun Xu, MD · Guangzhou Brain Hospital (Guangzhou Huiai Hospital)

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
12 Years
Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-05-15
Primary Completion
2021-12-30
Completion
2021-12-30

Countries

  • China

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04032795 on ClinicalTrials.gov