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Controlled Exposure of Healthy Nonsmokers to Secondhand and Thirdhand Cigarette Smoke

NCT04013256 · Status: SUSPENDED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 66

Last updated 2023-08-28

No results posted yet for this study

Summary

This study compares the health effects of dermal and inhalational exposure to thirdhand cigarette smoke to those of inhalational exposure to secondhand cigarette smoke in healthy, adult nonsmokers. Our hypothesis is that dermal exposure increases exposure to the tobacco specific carcinogen, NNK and may affect both endothelial function and epidermal integrity.

Conditions

  • Pollution; Exposure
  • Smoke Inhalation
  • Exposure to Pollution

Interventions

OTHER

Cigarette Smoke

Cigarette smoke, generated by a smoking machine and aged is used to reproduce exposure to secondhand and thirdhand cigarette smoke.

OTHER

Clean Air and Clean Clothing/Sham exposure

Clean air, created by high-efficiency particulate air (HEPA) and charcoal filtration and temperature and humidity control. Clean cotton clothing.

Sponsors & Collaborators

Principal Investigators

  • Suzaynn F Schick, PhD · University of California, San Francisco

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-01-20
Primary Completion
2024-10-31
Completion
2024-10-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04013256 on ClinicalTrials.gov