TEXTO : Total EXposure To Organic Pollutants

Summary

People are, especially in industrialized countries, exposed to a growing number of ubiquitous chemical substances. It thus increases human exposure pathways: diet, inhalation, soil and dust dermal contact…), notably for semi-volatile organic compounds. Diet is generally sought to contribute the most to total exposure for many chemicals, the relative contribution of each pathway is nevertheless poorly described, and can be different among populations. This is in particularly the case For young children, who can be more exposed via the environment, because of frequent contact with object and dust and hand to mouth behaviors. Children are in addition considered more sensitive to chemical risk due to their maturating systems.

In this context, the objective of this project is to characterize the young children's exposure to a particular class of semi volatile organic compounds. It will encompass the relative contribution of different pathways to the external dose, and to try to match the internal and external doses with a physiologically based pharmacokinetic (PBPK) model for molecules for which it is possible.

The present demand concerns a feasibility study on 2 children, for Perfluorinated Alkylated Substances (PFAS), used in numerous consumer products.

Conditions

• Healthy

Interventions

OTHER

Exposure study

Sampling of blood, food, water, air and dust and delivery of dietary questionnaire

Sponsors & Collaborators

• Institut de Recherche en Santé, Environnement et le Travail, France

  collaborator OTHER

• Laboratoire d'Etude des Résidus et Contaminants dans les Aliments

  collaborator UNKNOWN

• Institut national de l'environnement industriel et des risques

  collaborator INDUSTRY

• National Agency for Sanitary Safety of the Food of the Environment and Labor

  collaborator OTHER_GOV

• Rennes University Hospital

  lead OTHER

Principal Investigators

• Philippe Glorennec, PhD · Inserm UMR 1085 - Institut de Recherche sur la Santé, l'Environnement et le Travail

• Florence Rouget, MD · Rennes University Hospital

Study Design

Allocation

NA

Purpose

BASIC_SCIENCE

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

6 Months

Max Age

18 Months

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2014-09-30

Primary Completion

2015-05-31

Completion

2015-05-31

Countries

• France

Study Locations