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Effect of Sour Cherry Anthocyanins on Healthy Human Saliva

NCT05406011 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2023-05-16

No results posted yet for this study

Summary

The experiment is based on earlier research where it was proven that chewing gum usage with anthocyanin rich sour cherry extract significantly reduces the amount of human salivary alpha-amylase in unstimulated saliva samples and stimulated saliva samples taken in every 10 minutes till a half an hour as compared to placebo. The S. mutans counts' number on agar base cultures were greater in case of the stimulated samples of placebo and anthocyanin containing chewing gum groups.

The investigators' aims were to extend the background of the earlier established phenomena: The sour cherry (anthocyanin) containing chewing gum usage (around 2 weeks, daily 3 times) is beneficent on the human oral microflora and cytokine level/expression.

Conditions

  • Dental Caries

Interventions

DIETARY_SUPPLEMENT

Pelleted sour cherry (anthocyanin) containing chewing gum usage.

Dietary Supplement usage (daily 3 times for 2 weeks) with salivary sampling on fixed days (1., 4. and 7.) and daytime (between 12:00 and 14:00) of the week. Procedure: Scaling after a control period without sour cherry chewing gum usage (1 week).

DIETARY_SUPPLEMENT

Pelleted chewing gum for stimulated saliva sampling.

Stimulated saliva sampling after chewing a pelleted gum without active ingredient (used only before stimulated saliva sampling), during the whole experimental period (control and parallel with sour cherry chewing gum usage) with sampling on fixed days (1., 4. and 7.) and daytime (between 12:00 and 14:00) of the week.

PROCEDURE

Scaling

Scaling after a 1-week control period without chewing the sour cherry gum.

Sponsors & Collaborators

  • University of Debrecen

    lead OTHER

Principal Investigators

  • Judit Remenyik, ass. prof. · University of Debrecen, Institute of Food Technology

  • Kinga Bágyi, ass. prof. · University of Debrecen, Faculty of Dentistry

Study Design

Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-03-16
Primary Completion
2023-08-01
Completion
2024-12-31

Countries

  • Hungary

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05406011 on ClinicalTrials.gov