A Snapshot Adaptive Optics and Hyperspectral Autofluorescence Fundus Camera for Age-Related Macular Degeneration (AMD)

NCT03963817 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2026-02-24

No results posted yet for this study

Summary

This study proposes to use a new instrument (AO-OCT/AF: adaptive optics - optical coherence tomography/autofluorescence) combined with a data processing method to image the retinal pigment epithelium (RPE) of the eye in normal subjects and in subjects with age-related macular degeneration. (AMD). While currently there is no cure, with early diagnosis, vision loss can be slowed. The technology being developed for this project will be the first imaging modality that can provide both structural and molecular information about the retina in vivo and in 3D.

Conditions

Age Related Macular Degeneration

Interventions

DIAGNOSTIC_TEST

adaptive optics AO-OCT/AF instrument

Using the new adaptive optics AO-OCT/AF instrument, the study team will image 10 normal subjects in order to optimize image acquisition and interpretation.

DIAGNOSTIC_TEST

adaptive optics AO-OCT/AF instrument

Using the new adaptive optics AO-OCT/AF instrument, the study team will image 40 adult subjects with age-related macular degeneration (AMD) who have non-neovascular AMD and soft drusen or subretinal drusenoid deposits in the macula.

Sponsors & Collaborators

University of California, Los Angeles
collaborator OTHER
National Eye Institute (NEI)
collaborator NIH
Icahn School of Medicine at Mount Sinai
lead OTHER

Principal Investigators

Ronald Theodore Smith, MD, PhD · Icahn School of Medicine at Mount Sinai

Eligibility

Min Age: 60 Years
Max Age: 90 Years
Sex: ALL
Healthy Volunteers: Yes

Timeline & Regulatory

Start: 2023-09-06
Primary Completion: 2027-12-31
Completion: 2027-12-31

Countries

United States

Study Locations

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Entities

Companies