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Resting-state Functional Connectivity Throughout a Course of iTBS in Major Depression

NCT03944213 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2022-05-25

No results posted yet for this study

Summary

This study aims to investigate changes in functional connectivity over a four week treatment course with intermittent theta burst stimulation (iTBS) in patients with major depressive disorder (MDD). To this end, seven weekly resting-state fMRI (rs-fMRI) scans at 7 tesla (7T) will precede, accompany and follow the iTBS treatment course. By obtaining several samples of the modulatory effects of iTBS on functional connectivity networks and simultaneous measurements of the depressive symptoms it will be possible to assess the time course of changes in connectivity across different networks, and to assess the overall relationship between the network modulation and the antidepressant effects of the treatment over time.

Conditions

Interventions

DEVICE

intermittent theta burst stimulation (iTBS)

20 sessions of iTBS

Sponsors & Collaborators

  • Clemens Mielacher, University Hospital, Bonn

    collaborator UNKNOWN

  • Maximilian Kiebs, University Hospital, Bonn

    collaborator UNKNOWN

  • University Hospital, Bonn

    lead OTHER

Principal Investigators

  • René Hurlemann, Prof. · University Hospital, Bonn

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-07-23
Primary Completion
2023-02-01
Completion
2024-06-01

Countries

  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03944213 on ClinicalTrials.gov