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Intermittent Theta Burst Stimulation for Maintenance Therapy in Depression

NCT05732311 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2025-12-01

No results posted yet for this study

Summary

This is a randomized, multi-center, open-label study in which patients with depression who responded to an open-label treatment with intermittent theta burst stimulation (iTBS) will receive this procedure as maintenance therapy. The patients will be randomized to two study arms. The arms differ in the frequency of stimulation (standard iTBS (5 treatments every working day for one week) vs. accelerated iTBS (5 treatments in one day)). For purposes of effect size estimation an interim analysis will be done after half of the patients.

Conditions

Interventions

DEVICE

intermittend theta burst stimulation

intermittend theta burst stimulation

Sponsors & Collaborators

  • Berthold Langguth, MD, Ph.D.

    lead OTHER

Principal Investigators

  • Berthold Langguth, Prof. · University Hospital of Regensburg, Department of Psychiatry and Psychotherapy at the Bezirksklinikum

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-04-25
Primary Completion
2026-01-31
Completion
2026-02-28

Countries

  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05732311 on ClinicalTrials.gov