MedTrace Logo

Effect of Carnitine Supplementation and Resistance Training on Skeletal Muscle Function

NCT03907592 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2019-04-10

No results posted yet for this study

Summary

The primary aim of the current research project is to explore whether nutritional supplementation and resistance training might be combined to produce synergistic effects in the prevention of muscle loss during aging.

A secondary aim of this project is to investigate the effects of carnitine with leucine supplementation, in comparison to carnitine supplementation alone, on muscle strength and body composition.

The hypothesis is that resistance training combined with nutritional supplementation have a more beneficial effect than resistance training alone in the prevention of muscle loss during aging. Leucine stimulates carnitine transport into the muscle cells, which improve mitochondrial capacity. Modification in energetic of skeletal muscle affects the body composition and muscle performance.

Conditions

Interventions

DIETARY_SUPPLEMENT

L-carnitine supplementation

Supplementation of 1000 mg L-carnitine-L-tartrate in combination with 3000 mg L-leucine per day throughout the study period.

DIETARY_SUPPLEMENT

Leucine supplementation

Supplementation of 4000 mg L-leucine per day throughout the study period.

PROCEDURE

Resistance training

Resistance training at the gym, twice a week for 24 weeks (48 training units in total).

Sponsors & Collaborators

  • Medical University of Gdansk

    collaborator OTHER

  • National Science Centre, Poland

    collaborator OTHER_GOV

  • Gdansk University of Physical Education and Sport

    lead OTHER

Principal Investigators

  • Robert A Olek, PhD · Gdansk University of Physical Education and Sport

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Max Age
72 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-09-01
Primary Completion
2018-07-07
Completion
2018-07-07

Countries

  • Poland

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03907592 on ClinicalTrials.gov