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Protein Intake and Resistance Training in Aging

NCT01890382 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2019-02-15

No results posted yet for this study

Summary

Resistance training combined with protein or amino acids supplementation has been shown to be promising for mitigating age-related disabilities and comorbidities. Randomized controlled trials supporting this possibility are still scarce. These series of clinical trials aim to investigate the chronic effects of different strategies of protein and derivatives supplementation in association with resistance training on selected health-related parameters in pre-frail and frail elderly.This is a 16-month, double-blind, randomized, placebo-controlled, parallel-group clinical trial involving a series of investigations. Participants will be divided into nine groups, allowing the assessement of the effects of (1) isolated leucine supplementation; (2) protein source (whey vs. soy); (3) combination of whey protein and creatine; and (4) sexual dimorphism to the response of protein intake plus resistance training (men vs. women). All participants will undergo a supervised, resistance training program.

Conditions

  • Frail Elderly Syndrome

Interventions

DIETARY_SUPPLEMENT

Whey protein

30 g in total; twice a day (morning and evening)

DIETARY_SUPPLEMENT

whey plus creatine

whey protein combined with creatine (30 g and 6.0 g in total; twice a day, respectively)

DIETARY_SUPPLEMENT

leucine supplementation

7.5 g/d in total; three times per day

DIETARY_SUPPLEMENT

soy protein

30 g in total; twice a day

DIETARY_SUPPLEMENT

creatine

6.0 g in total; twice a day

DIETARY_SUPPLEMENT

placebo

Sponsors & Collaborators

  • University of Sao Paulo

    lead OTHER

Principal Investigators

  • Bruno Gualano, Professor · University of Sao Paulo

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-10-01
Primary Completion
2017-08-30
Completion
2017-08-30

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01890382 on ClinicalTrials.gov