Contribution of Functional MRI in Assessment of Auditory Processing Disorders

Summary

Auditory Processing Disorder (APD) affects 0.5-7% of the pediatric population. This disorder is responsible for a child's low hearing ability. The diagnosis of APD is difficult because of polymorphic symptoms possibly entangled with other difficulties (learning, communication, attention ...). There is currently no gold standard in the literature for diagnosing APD. Investigators opened multidisciplinary consultation for the children suspected of APD. The purpose of this study is to analyze the results of the multidisciplinary assessment performed on these children (audiometry, cortical auditory brainstem response (ABR), behavioral assessment, psychometric evaluation, genetic analysis) to the results of functional MRI (fMRI) at rest and in activation. The goal is to find radiological MRI-fMRI markers in these patients that improve the diagnosis of APD.

Investigators will compare the f-MRI results between three groups of children in order to find specific radiological markers of APD :

* group 1 : children diagnosed with an Auditory Processing Disorder (APD)
* group 2 : children suspect of APD
* group 3 : children without APD (controls)

Conditions

• Auditory Processing Disorders

Interventions

DIAGNOSTIC_TEST

functional MRI

Additional sequence (DTI) and functional MRI (fMRI) during the MRI which is done as part of the usual care

DIAGNOSTIC_TEST

Automated Cortical Brainstem Auditory Evoked Potential

Automated Cortical Brainstem Auditory Evoked Potential correspond to a non-invasive EEG

GENETIC

whole exome sequencing

A study of all the DNA-encoding exons of the child/parent from a sample taken as part of the usual care

DIAGNOSTIC_TEST

Standard Cortical Brainstem Auditory Evoked Potential

Standard Cortical Brainstem Auditory Evoked Potential correspond to a non-invasive EEG

DIAGNOSTIC_TEST

multidisciplinary consultation

multidisciplinary consultation is composed of: * an ENT consultation and audiometry * a speech therapy assessment * a psychometric evaluation

Sponsors & Collaborators

• URC-CIC Paris Descartes Necker Cochin

  collaborator OTHER

• Assistance Publique - Hôpitaux de Paris

  lead OTHER

Principal Investigators

• Isabelle Rouillon, MD, PhD · Assistance Publique - Hôpitaux de Paris

Study Design

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

7 Years

Max Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2020-09-02

Primary Completion

2023-10-10

Completion

2023-10-10

Countries

• France

Study Locations