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Correlation of Radiological Lesions With Vestibular Function in Patients With Bilateral Vestibulopathy

NCT04070937 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2021-08-25

No results posted yet for this study

Summary

In 2014 radiologic lesions were detected at one or more semicircular canals using CT and MR imaging of temporal bone in subjects carrying the p.P51S mutation in COCH. These lesions are believed to present at more advanced stages of the hearing and vestibular deterioration. Since then, other authors have described similar lesions in advanced non-genetic hearing and vestibular impairment as well.

The purpose of this study is therefore to assess the radiologic investigation using CT and MR imaging of temporal bone to all subjects presenting with bilateral vestibulopathy, using the Barany criteria, compared to the p.P51S population.

Conditions

  • Hearing Loss, Sensorineural
  • Bilateral Vestibular Deficiency
  • DFNA9
  • Radiology

Interventions

DIAGNOSTIC_TEST

vestibular test 1

videonystagmography

DIAGNOSTIC_TEST

vestibular test 2

video head impulse test

DIAGNOSTIC_TEST

vestibular evoked myogenic potentials

vestibular evoked myogenic potentials to measure the function of otolith organs

DIAGNOSTIC_TEST

audiometry

tonal liminar audiometric thresholds

DIAGNOSTIC_TEST

CT and MR imaging of temporal bone

Ct and MR imaging of temporal bone

GENETIC

p.P51S mutation

analysis of presence of p.P51S mutation in COCH

Sponsors & Collaborators

  • Jessa Hospital

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-09-01
Primary Completion
2026-10-30
Completion
2026-10-30

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04070937 on ClinicalTrials.gov