Imaging Biomarkers of the Effects of a Mixed Exercise Program

Summary

The aim is quantify, correlate and establish the diagnostic and prognostic value of the variation of the image biomarkers obtained by magnetic resonance (muscle volume, morphological, biochemical and structural biomarkers) longitudinally in fragile or pre-frail elders with sarcopenia after a mixed physical training of strength and myofascial self-conditioning. This project is based on an, longitudinal, prospective, controlled, randomized, intervention study and blind for the researchers responsible for the study. 60 elderly with sarcopenia and frailty (Intervention Group, n=30; Control Group, n=30) will participate in the study. Intervention Group participants will perform 6-months mixed exercise program consisting in high-intensity strength training and self-myofascial conditioning. Data will be take trough 2 measurements that will be take place at baseline and post-intervention. Criteria of frailty, criteria of sarcopenia, sociodemographic, clinics, kinanthropometric, functional, nutritional and confusing variables will be evaluated. Moreover, magnetic resonance images will be performed to obtain muscle volume, morphological, biochemical and structural biomarkers.

Conditions

• Sarcopenia

Interventions

OTHER

Mixed exercise program

A progressive program of high intensity strength and myofascial conditioning will be carried out in 2 non-consecutive weekly sessions (24 weeks). Each session will include: A) Warm up on a cycle ergometer B) Strength circuit: 6 exercises will be included to strengthen different muscle groups (2 in the upper extremities, 2 in the trunk and 2 in the lower extremities). 3 sets of 10-15 repetitions until the failure. The load will be set to 70% of 1 maximal resistance. C) Self-myofascial conditioning: 10 repetitions, in the direction of the fibres of each muscle group, with different materials. 7 muscle groups will be worked (quadriceps, hamstrings, abductors, gluteus, pectoralis, full back and trapezius). D) At the end, static stretches will be performed

Sponsors & Collaborators

• Fundación Universidad Católica de Valencia San Vicente Mártir

  collaborator OTHER

• Quironsalud

  collaborator OTHER

• University of Valencia

  lead OTHER

Principal Investigators

• Francisco Martinez Arnau, PhD · Universitat de Valencia

• Roberto Sanz Requena, PhD · Hospital QuironSalud - Hospital Universitario La Fe (GIBI)

• Ana Pablos Monzó, PhD · Fundación Universidad Católica de Valencia

• Pilar Pérez-Ros, PhD · Fundación Universidad Católica de Valencia

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

70 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-02-06

Primary Completion

2020-04-15

Completion

2020-11-02

Countries

• Spain

Study Locations