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Stress-Induced Inflammation and Reward Processing

NCT03828604 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 57

Last updated 2019-02-05

No results posted yet for this study

Summary

Anhedonia, or loss of interest or pleasure, is a key feature of depression and transdiagnostic construct in psychopathology. Both theory and compelling evidence from preclinical models implicates stress-induced inflammation as a key psychobiological pathway to anhedonic behavior; however, this pathway has not been demonstrated in human models. Further, although anhedonia may reflect dysregulation in multiple dimensions of reward, the extent to which stress-induced inflammation alters these dimensions is unclear. The current placebo controlled study used a standardized laboratory stressor task to elicit an inflammatory response in a sample of a healthy young women and evaluate effects of stress-induced inflammation on multiple behavioral indices of reward processing.

Conditions

  • Stress, Psychological

Interventions

BEHAVIORAL

Stress; Trier Social Stress Task

Standardized acute psychosocial stressor

BEHAVIORAL

Placebo Trier Social Stress Task

Active control version of the TSST

Sponsors & Collaborators

Principal Investigators

  • Chloe C Boyle, PhD · University of California, Los Angeles

  • Julienne E Bower, PhD · University of California, Los Angeles

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
28 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-05-12
Primary Completion
2017-12-08
Completion
2018-05-09

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03828604 on ClinicalTrials.gov