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The Dallas Asthma Brain and Cognition (ABC) Study

NCT03794856 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 130

Last updated 2025-07-09

No results posted yet for this study

Summary

Asthma is a chronic inflammatory airway disease that leads to episodic symptom exacerbations, which exerts a substantial burden on quality of life and can influence other health domains if not adequately controlled. Asthma prevalence rates have increased in the past decade, affecting 8.4% (25.7 million people) of the United States population. The economic costs of asthma have been estimated annually with $56 billion in the US alone. Despite progress in pharmacological treatment, overall asthma control remains unsatisfactory and treatment non-adherence is extremely high. Asthma is particularly under diagnosed and understudied in aging adults. This problem will increase in coming decades given demographic trends and will disproportionally contribute to the societal and personal economic costs associated with asthma treatment and management. In the proposed 4-year project we will evaluate, in a two-session assessment recruiting a total of 126 asthma patients and 66 healthy controls aged 40-69 years, the extent to which asthma and aging are associated with changes in cognition and brain chemistry, structure, and function.

Conditions

Interventions

OTHER

Functional and Structural Magnetic Resonance Imaging (research grade)

Brain structure and function will be compared in middle to late-age adults with asthma compared to healthy adults.

OTHER

Cognitive Function Testing (non-diagnostic)

Multiple domains of cognitive functioning will be investigated, including processing speed, executive functioning/working memory and episodic memory.

OTHER

Asthma and Psychological Questionnaires (non-diagnostic)

Participants will fill out asthma and psychological questionnaires (non-diagnostic)

Sponsors & Collaborators

  • Southern Methodist University

    collaborator OTHER

  • University of Texas Southwestern Medical Center

    lead OTHER

Principal Investigators

  • E. Sherwood Brown, MD, PhD · UT Southwestern Medical Center

Eligibility

Min Age
40 Years
Max Age
69 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-02-21
Primary Completion
2025-05-28
Completion
2025-05-28

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03794856 on ClinicalTrials.gov