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Microglia Activation in Asthma

NCT04307667 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2025-08-26

No results posted yet for this study

Summary

The goal of this clinical trail is to learn about how asthma influences brain function. The main questions it aims to answer are:

* How airway inflammation in asthma affects the brain; and,
* Whether airway inflammation in asthma is related to symptoms of depression and anxiety

Over the course of 6 visits, participants will:

* Complete questionnaires
* Complete computer tasks
* Undergo allergy skin test
* Undergo breathing tests including two whole lung allergen challenges
* Give four blood samples
* Complete brain imaging scans

Conditions

Interventions

BIOLOGICAL

Whole lung antigen challenge (WLAC)

Whole lung antigen challenge with cat hair, house dust mite, or short ragweed allergen extracts.

RADIATION

[18F]FEPPA

\[18F\]FEPPA is a radiotracer selective for translocator protein (TSPO) binding, which is elevated in activated microglia.

Sponsors & Collaborators

  • National Institute on Aging (NIA)

    collaborator NIH

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • University of Wisconsin, Madison

    lead OTHER

Principal Investigators

  • Melissa Rosenkranz · Center for Healthy Minds

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-12-17
Primary Completion
2028-08-01
Completion
2028-08-01
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04307667 on ClinicalTrials.gov