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Comparison of Skin Sympathetic Nerve Activity According to Different Anesthetics

NCT03763305 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2022-05-11

No results posted yet for this study

Summary

Skin sympathetic nerve activity (SKNA) has recently been discovered from the electrocardiogram obtained from healthy volunteers. The raw physiologic electric signal from electrodes placed on the skin was reprocessed through filtering and integration using software to produce the SKNA signal. However, no study has yet provided knowledge on the effect of anesthetics on SKNA during general anesthesia.

Conditions

  • SKNA According to Different Anesthetics

Interventions

DRUG

Propofol continuous infusion

Propofol intravenous continuous infusion for anesthetic induction and maintenance

DRUG

Remifentanil

Remifentanil intravenous continuous infusion for anesthetic induction and maintenance

DRUG

Sevoflurane

Study participants receive fentanyl 1mcg/kg and propofol 1.5\~2mg/kg for induction of general anesthesia. For maintenance of anesthesia, desflurane is used to maintain 1 age-related minimum alveolar concentration (MAC).

DRUG

Desflurane

1 age-related minimum alveolar concentration (MAC) of desflurane inhalation for anesthetic maintenance

DRUG

Propofol bolus injection

Propofol intravenous injection for anesthetic induction

DRUG

Fentanyl

Fentanyl intravenous injection for anesthetic induction

Sponsors & Collaborators

  • Seoul National University Hospital

    lead OTHER

Principal Investigators

  • Yunseok Jeon, MD, PhD · Seoul National University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-01-01
Primary Completion
2023-12-31
Completion
2023-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03763305 on ClinicalTrials.gov