Systemic Cross-talk Between Brain, Gut, and Peripheral Tissues in Glucose Homeostasis: Effects of Exercise Training

Summary

Obesity and insulin resistance are worldwide epidemic and taking a major public health toll. Obesity also increases the risk for cognitive impairment which is also an increasing medical, societal, and economic challenge. The ultimate goal of this proposal is to develop a statistical model to assess systemic cross-talk between brain, peripheral tissues, gut microbiota and glucose metabolism. Integrated with exercise training intervention the results will be utilized to provide disease risk profiling and personalized predictions of exercise training as a drug free treatment for insulin resistance and type 2 diabetes.

Conditions

• Obesity
• Insulin Resistance
• Type2 Diabetes
• Exercise Training

Interventions

BEHAVIORAL

Exercise training

Subjects are required to exercise four times a week during six months. Exercise training consists of endurance training, resistance training and high-intensity interval training adjusted to subject's fitness level.

Sponsors & Collaborators

• University of Helsinki

  collaborator OTHER

• University of Eastern Finland

  collaborator OTHER

• Turku University Hospital

  collaborator OTHER_GOV

• Academy of Finland

  collaborator OTHER

• Finnish Cultural Foundation

  collaborator OTHER

• Diabetes Research Foundation, Finland

  collaborator OTHER

• Juho Vainio Foundation

  collaborator OTHER

• University of Turku

  lead OTHER

Principal Investigators

• Jarna Hannukainen, PhD · Turku PET Cente, University of Turku, Finland

Study Design

Allocation

NA

Purpose

PREVENTION

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

30 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2019-01-30

Primary Completion

2021-10-31

Completion

2021-10-31

Countries

• Finland

Study Locations