Pharmacokinetics Assessing Bioavailability of Gingerols and Shogaols of Five Ginger Extracts

Summary

The objective of this study is to assess bioavailability of total gingeroids, free gingerols and shogaols, so as their glucuronide and sulfate metabolites, in the plasma, after consumption of a single dose of 5 different ginger extracts. These five extracts have the same quantity of active substance but with different titration (1.6%, 5%, 39%, 26% and 26% NOP80).

Conditions

• Healthy Subject

Interventions

DIETARY_SUPPLEMENT

Tested product n°1

1 capsule (26% of gingerol/shogaol in 100 mg) to consume one time for each subject, at one experimental session (random assignment), with 250 mL of water (consumption at T0 time-point of the kinetic)

DIETARY_SUPPLEMENT

Tested product n°2

1 capsule (38.6% of gingerol/shogaol in 74.9 mg) to consume one time for each subject, at one experimental session (random assignment), with 250 mL of water (consumption at T0 time-point of the kinetic)

DIETARY_SUPPLEMENT

Tested product n°3

2 capsules (6.8% of gingerol/shogaol in 424.3 mg) to consume one time for each subject, at one experimental session (random assignment), with 250 mL of water (consumption at T0 time-point of the kinetic)

DIETARY_SUPPLEMENT

Tested product n°4

1 capsule (27% of gingerol/shogaol in 104.9 mg) to consume one time for each subject, at one experimental session (random assignment), with 250 mL of water (consumption at T0 time-point of the kinetic)

DIETARY_SUPPLEMENT

Tested product n°5

6 capsules (1.6% of gingerol/shogaol in 1806.25 mg) to consume one time for each subject, at one experimental session (random assignment), with 250 mL of water (consumption at T0 time-point of the kinetic)

Sponsors & Collaborators

• Biofortis Mérieux NutriSciences

  collaborator OTHER

• Givaudan France Naturals

  lead INDUSTRY

Principal Investigators

• Romain Le Cozannet, PhD · Givaudan France Naturals

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

55 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2018-10-15

Primary Completion

2018-12-07

Completion

2018-12-07

Countries

• France

Study Locations