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Association Between Mitochondrial DNA Content and Risk of Acute Leukemia

NCT03595969 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2020-07-10

No results posted yet for this study

Summary

Compelling epidemiological evidence indicates that alterations of mitochondrial DNA, including mutations and abnormal content of mitochondrial DNA (mtDNA), are associated with the initiation and development of acute lymphoblastic leukemia (ALL).The aim of this study was to explore association between mtDNA content in peripheral blood cells could be used as a risk predictor for ALL.

Conditions

  • Lymphoblastic Leukemia in Children

Interventions

DIAGNOSTIC_TEST

Relative copy number of mitochondrial DNA

Mitochondria are responsible for multiple cellular functions including regulation of energy production, modulation of oxidation-reduction status, generation of reactive oxygen species and apoptosis. Each mitochondrion possesses multiple copies of a mitochondrial genome comprised of independently replicating double stranded DNA (mtDNA).

Sponsors & Collaborators

  • Air Force Military Medical University, China

    lead OTHER

  • Chinese Academy of Medical Sciences

    collaborator OTHER

Eligibility

Max Age
16 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-11-01
Primary Completion
2019-10-01
Completion
2019-10-01

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03595969 on ClinicalTrials.gov