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A Clinical Diagnostic System for Intrinsic Acute Kidney Disease

NCT06606522 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1360

Last updated 2024-09-23

No results posted yet for this study

Summary

The goal of this observational cross-sectional study is to develop a clinical diagnostic system for intrinsic acute kidney disease (AKD) to help clincians make non-invasive diagnosis when a kidney biopsy is not available. The main questions it aims to answer are:

1. Can a clinical model comprised of common clinical indexes help diagnose AKD ?
2. Can a combinition of several urinary biomarkers help diagnose AKD ? The study will be conducted in retrospective cohorts of patients with AKD undergoing kidney biopsy. The gold standard of the study is histological diagnosis of AKD. The model will be developed in a derivation cohort from one center, and will be further externally validated in a multicent cohort. The urinary biomarkers will only be tested in the derivation cohort.

Conditions

  • Acute Kidney Disease

Interventions

DIAGNOSTIC_TEST

Clinical model

Clinical model: a clinical model based on basic demorgraphic information and commonly executed laboratory tests to differentiate different pathological types of intrinsic AKD.

DIAGNOSTIC_TEST

Urinary biomarkers

Urinary biomarkers: biomarkers help differentiate different pathological types of intrinsic AKD.

Sponsors & Collaborators

  • Affiliated Hospital of Hebei University

    collaborator OTHER

  • Beijing Miyun Hospital

    collaborator UNKNOWN

  • Dongzhimen Hospital, Beijing

    collaborator OTHER

  • Taiyuan Central Hospital of Shanxi Medical University

    collaborator OTHER

  • Peking University First Hospital

    lead OTHER

Principal Investigators

  • Li Yang, Professor · Peking University First Hospital

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-06-01
Primary Completion
2024-06-30
Completion
2024-09-09

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06606522 on ClinicalTrials.gov