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Metallic Taste Before, During and After Treatment of Head and Neck Cancer

NCT03558789 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2025-09-08

No results posted yet for this study

Summary

Metallic taste in head and neck cancer is widely under-estimated in the literature. Its causes are multiple and poorly defined. Though it has a strong impact on the nutritional status.

The main objective of the TORCAD project is to test the hypothesis that intraoral lipoperoxidation is associated to metallic taste onset before, during and after treatment of head and neck cancer (HNC).

The secondary goals are to evaluate the involvement of others physiopathological factors in metallic taste: (i) additional chemical modification in the saliva; (ii) release of inhibition of the facial nerve on the glossopharyngeal nerve; presence of an intraoral electric current; food pleasantness and acceptability; quality of life.

Conditions

  • Metallic Taste

Interventions

BIOLOGICAL

bovine lactoferrin

mouthwash

Sponsors & Collaborators

  • Centre Hospitalier de Valence

    lead OTHER

Principal Investigators

  • Gilles Feron, PhD · Centre des Sciences du Goût et de l'Alimentation

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-04-26
Primary Completion
2022-12-01
Completion
2023-12-01

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03558789 on ClinicalTrials.gov