Diet Modulation of Bacterial Sulfur and Bile Acid Metabolism and Colon Cancer Risk

Summary

Determine in the context of a controlled crossover diet-intervention trial the role of taurocholic acid metabolism by gut bacteria in African American subjects at elevated risk for colorectal cancer (CRC). Two isocaloric diets, an animal-based diet high in taurine and saturated fat (HT-HSAT) and a plant-based, low in taurine and low saturated fat (LT-LSAT) will be used to determine the extent to which the relationship between diet (independent variable) and mucosal markers of CRC risk including epithelial proliferation, oxidative stress, DNA damage, and primary and secondary bile acid pools and biomarkers of inflammation (dependent variables) is explained by the abundance of sulfidogenic bacteria and hydrogen sulfide (H2S) concentrations \&/or deoxycholic acid (DCA) and DCA-producing bacteria clostridium scindens (mediator variables).

Conditions

• Colorectal Cancer

Interventions

OTHER

High taurine and saturated fat diet

This is a 3-week (21 day) isocaloric Western-type diet with all meals, snacks, beverages and condiments provided.

OTHER

Low in taurine and saturated fat diet

This is a 3-week (21 day) isocaloric largely plant-based diet with all meals, snacks, beverages and condiments provided.

Sponsors & Collaborators

• Rush University Medical Center

  collaborator OTHER

• National Cancer Institute (NCI)

  collaborator NIH

• University of Illinois at Chicago

  lead OTHER

Principal Investigators

• Lisa Tussing-Humphreys, PhD, MS, RD · University of Illinois at Chicago

• Ece Mutlu, MD, MS, MBA · Rush University Medical Center

• H. Rex Gaskins, PhD · University of Illinois at Urbana-Champaign

• Jason Ridlon, PhD · University of Illinois at Urbana-Champaign

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

45 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2018-08-01

Primary Completion

2021-12-01

Completion

2021-12-01

Countries

• United States

Study Locations