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Safety and Feasibility of Preoperative and Intraoperative Image-Guided Resection of Gliomas

NCT03542409 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 53

Last updated 2025-11-20

No results posted yet for this study

Summary

This study evaluates the use of specialized magnetic resonance imaging (MRI) techniques including magnetic resonance (MR) perfusion and 2-hydroxyglutarate (2HG) spectroscopy in the surgical treatment of gliomas.

Cohort 1 participants will undergo an MR perfusion scan or 2-HG spectroscopy prior to surgery and intra-operatively.

Cohort 2 participants will only undergo standard of care imaging and tumor acquisition. Participant participation will end at the completion of surgery and will be transitioned to standard of care follow-up.

Conditions

  • Brain Tumor Adult

Interventions

OTHER

MR Perfusion Scan

MR perfusion scan before and during surgery.

OTHER

2HG Spectroscopy Scan

2HG spectroscopy scan before and during surgery.

OTHER

Standard of Care Intraoperative MRI

The standard of care intraoperative MRI sequences used routinely will be sufficient for these 10 new samples.

Sponsors & Collaborators

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-02-15
Primary Completion
2021-10-28
Completion
2026-07-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03542409 on ClinicalTrials.gov