Image Guided Therapy in the Treatment of Gliomas

Summary

RATIONALE: New imaging techniques using magnetic resonance imaging give better tumor definition, thus may lead to better tumor targeting and avoid damaging critical parts of normal brain.

PURPOSE: This phase I/II trial is studying how well image-guided therapy works in treating patients with newly diagnosed intracranial glioma.

Conditions

• Glioma

Interventions

PROCEDURE

Diffusion-weighted magnetic resonance imaging

Undergo diffusion-weighted MRI

PROCEDURE

Perfusion-weighted magnetic resonance imaging

Undergo perfusion-weighted magnetic resonance imaging

PROCEDURE

Functional magnetic resonance imaging

Undergo functional MRI

PROCEDURE

Magnetic resonance spectroscopic imaging

Undergo MR spectroscopic imaging

PROCEDURE

Therapeutic conventional surgery

Undergo maximal surgical resection

PROCEDURE

Quality-of-life assessment

Ancillary studies

PROCEDURE

Radiation therapy treatment planning/simulation

Undergo IMRT planning

PROCEDURE

Intensity-modulated radiation therapy

Undergo intensity-modulated radiation therapy

OTHER

Questionnaire administration

Ancillary studies

Sponsors & Collaborators

• NYU Langone Health

  lead OTHER

Principal Investigators

• Joshua Silverman, MD · NYU Langone Health

Study Design

Allocation

NA

Purpose

DIAGNOSTIC

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

7 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2009-08-31

Primary Completion

2014-04-30

Completion

2014-04-30

Countries

• United States

Study Locations