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Study About the Validity of MRS-guided Resection on Prognosis High-grade Glioma Gliomas

NCT02795364 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2016-06-10

No results posted yet for this study

Summary

Gliomas,especially high-grade glioma ,are the most common primary malignant brain tumor in adults,yet outcomes from this aggressive neoplasm remain dismal.The extent of resection is one of the most essential factors that influence the outcomes of glioma resection.However, conventional structural imaging has failed to accurately delineate glioma margins because of tumor cell infiltration. the investigators have finished few project that suggest the feasibility of Magnetic Resonance Spectrum(MRS)-guided resection,unfortunately, lacking sufficient clinical evidence.This prospective cohort study is to provide a clinical evidence for the validity of MRS-guided resection in patients with HGG .

Conditions

  • Glioma
  • Anaplastic Oligoastrocytoma
  • Glioblastomas (GBM)

Interventions

PROCEDURE

Structural Image Guidance

Resecting the tumor in accordance with the margin on MRI T1W-enhanced delineation

PROCEDURE

Metabolic Image Guidance

Aggressive resecting of the tumor in accordance with the margin on MRS CNI delineation

Sponsors & Collaborators

  • Huashan Hospital

    lead OTHER

Principal Investigators

  • Jinsong Wu, Professor · Huashan Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-06-30
Primary Completion
2017-05-31
Completion
2018-05-31

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02795364 on ClinicalTrials.gov