Dose Escalation and Dose Expansion Study of MDX2004 in Participants With Advanced Tumors
NCT07110584 · Status: RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 235
Last updated 2026-03-05
Summary
This study is designed to characterize the safety, tolerability, and anti-tumor activity of MDX2004 in patients with advanced tumors.
Conditions
- Advanced Tumors
Interventions
- DRUG
-
MDX2004
MDX2004 intravenous infusion
Sponsors & Collaborators
-
ModeX Therapeutics, An OPKO Health Company
lead INDUSTRY
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-10-01
- Primary Completion
- 2031-06-30
- Completion
- 2031-06-30
Countries
- Australia
- Israel
Study Locations
More Related Trials
-
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S
NCT04430842 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Evaluate the Safety, Pharmacokinetics, and Antitumor Activity of AK117 as Monotherapy or in Combination With AK104
NCT04349969 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase 1 Trial of ERX-315 in Participants With Advanced Solid Tumors
NCT06533332 ·Status: RECRUITING ·Phase: PHASE1
-
A First-in-Human Study of CDK-002 (exoSTING) in Subjects With Advanced/Metastatic, Recurrent, Injectable Solid Tumors
NCT04592484 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study of DM005 in Patients With Advanced Solid Tumors
NCT06515990 ·Status: RECRUITING ·Phase: PHASE1
-
To Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of ABN401 in Patients With Advanced Solid Tumors and Non-Small Cell Lung Cancer Harboring c-MET Dysregulation
NCT04052971 ·Status: COMPLETED ·Phase: PHASE1
-
Study of MHB036C in Participants With Advanced or Metastatic Solid Tumors
NCT05642949 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Clinical Activity of GSK5733584 for Injection in Participants With Advanced Solid Tumors
NCT06431594 ·Status: RECRUITING ·Phase: PHASE1
-
A Study to Evaluate the Safety, Pharmacokinetics, and Antitumor Activity of AK114
NCT05200273 ·Status: UNKNOWN ·Phase: PHASE1
-
Subjects With Advanced or Metastatic Solid Tumor Malignancies
NCT05474859 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
A Study of DXC006 in Patients With Advanced Solid Tumors and Hematologic Malignancies
NCT06224855 ·Status: RECRUITING ·Phase: PHASE1
-
Pharmacokinetic and Safety Study of MRX-2843 in Adults With Relapsed/Refractory Advanced and/or Metastatic Solid Tumors
NCT03510104 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Antitumor Activity of ALK202 in Participants with Advanced Solid Tumors
NCT06707610 ·Status: RECRUITING ·Phase: PHASE1
-
A Dose Escalation/Expansion Study of MDK-703 in Patients With Advanced or Metastatic Solid Tumors
NCT05716295 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
IMX-110 in Patients With Advanced Solid Tumors
NCT03382340 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Study of the Safety, Pharmacokinetics, and Antitumor Activity of AK105 in Subjects With Advanced Solid Tumors
NCT03352531 ·Status: COMPLETED ·Phase: PHASE1
-
MSX-122 Administered Orally in Patients With Refractory Metastatic or Locally Advanced Solid Tumors
NCT00591682 ·Status: SUSPENDED ·Phase: PHASE1
-
A Study of D3S-001 Monotherapy or Combination Therapy in Subjects With Advanced Solid Tumors With a KRAS p.G12C Mutation
NCT05410145 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Multiple Dose Study In Cancer Patients: Safety and Tolerability of BMS-754807 in Advanced or Metastatic Solid Tumors
NCT00569036 ·Status: COMPLETED ·Phase: PHASE1
-
HX044,FIH Study in Patients with Advanced Solid Tumor Malignancies
NCT06649708 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Dose Escalation Study With MK-2206 in Patients With Locally Advanced or Metastatic Solid Tumors (MK-2206-002)
NCT00670488 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of PYX-201 in Advanced Solid Tumors
NCT05720117 ·Status: RECRUITING ·Phase: PHASE1
-
A Study to Assess the Safety and Pharmacokinetics of MOXR0916 and Atezolizumab (Also Known as MPDL3280A or Anti-PD-L1) in Participants With Locally Advanced or Metastatic Solid Tumors
NCT02410512 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Investigate ANS014004 in Participants With Locally Advanced or Metastatic Solid Tumors
NCT06307795 ·Status: RECRUITING ·Phase: PHASE1
-
MSB0011359C (M7824) in Metastatic or Locally Advanced Solid Tumors
NCT02517398 ·Status: COMPLETED ·Phase: PHASE1