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Effects of Curcumin in Patients in Chronic Kidney Disease

NCT03475017 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2023-12-15

No results posted yet for this study

Summary

Many studies have been conducted to identify therapeutic strategies to modulate inflammation and oxidative stress, complications that contribute to the increased morbidity and cardiovascular mortality in patients with chronic kidney disease (CKD). Among several non-pharmacological strategies, the use of bioactive compounds has emerged as a potential approach to reduce these complications in CKD patients. In this context, turmeric/curcumin may have positive consequences in terms of cardiovascular and nephroprotection because of its antibacterial, antiviral, anti-inflammatory and anti-oxidative effects. The aim of this study is the role of curcumin as a nutritional strategy to reduce cardiovascular risk factors as inflammation and oxidative stress in CKD patients.

Conditions

  • Chronic Kidney Diseases

Interventions

DIETARY_SUPPLEMENT

Active Comparator: Supplement A

The patients will receive 3 capsules per day containing 500mg of curcumin and 5mg of piperine for 4 weeks

DIETARY_SUPPLEMENT

Placebo Comparator: Supplement B

The patients will receive 3 capsules of placebo per day containing 500mg of maize starch for 4 weeks

Sponsors & Collaborators

  • Denise Mafra

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-02-22
Primary Completion
2021-04-29
Completion
2021-12-30

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03475017 on ClinicalTrials.gov