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Intermittent Energy Restriction and Chewing on Neural Stem Cell Ageing and Adult Hippocampal Neurogenesis Associated Cognition

NCT03457870 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 123

Last updated 2021-02-18

No results posted yet for this study

Summary

Extended bouts of periodic mastication and intermittent energy restriction (IER) may improve cognitive performance in the context of adult hippocampal neurogenesis in an ageing population. A randomised controlled parallel design trial will determine the impact of a 3 month IER diet (2 consecutive days of very low calorie diet and 5 days of normal eating) and a mastication intervention (1 piece of gum chewed for 10 minutes 3 times a day) in comparison to a control on neurogenesis-associated cognitive measures and circulating levels of the anti-ageing protein Klotho.

Conditions

Interventions

BEHAVIORAL

Intermittent Energy Restriction

Dietary advice to follow a 5:2 diet.

BEHAVIORAL

Chewing

Asked to chew 1 piece of gum for 10 minutes 3 times a day.

BEHAVIORAL

Chewing + Intermittent Energy Restriction

Dietary advice to follow a 5:2 diet. Asked to chew 1 piece of gum for 10 minutes 3 times a day.

Sponsors & Collaborators

Principal Investigators

  • Sandrine Thuret, PhD · King's College London

  • Wendy L Hall, PhD · King's College London

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
60 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-04-18
Primary Completion
2020-03-23
Completion
2020-03-23

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03457870 on ClinicalTrials.gov