Neuroimaging Biomarker for Seizures

Summary

This multi-site study will examine patients with epilepsy (ES) following head injury \[i.e., posttraumatic epilepsy (PTE)\] and posttraumatic psychogenic Non-epileptic seizures (PNES) and will compare them to patients with traumatic brain injury (TBI) who do not have seizures using functional neuroimaging.

Conditions

• Seizure Disorder
• Seizure Disorder, Post Traumatic
• Traumatic Brain Injury
• Non-Epileptic Seizure
• Conversion Disorder
• Magnetic Resonance Imaging
• Head Injury
• Epilepsy

Interventions

BEHAVIORAL

Cognitive Behavioral Therapy for Seizures

CBT-informed psychotherapy for patients with PNES and PTE

OTHER

Standard Medical Care

Observational - standard medical care

Sponsors & Collaborators

• University of Alabama at Birmingham

  collaborator OTHER

• Rhode Island Hospital

  collaborator OTHER

• Birmingham, Alabama VA Medical Center

  collaborator FED

• United States Department of Defense

  collaborator FED

• Ocean State Research Institute, Inc.

  collaborator OTHER

• Brown University

  collaborator OTHER

• Providence VA Medical Center

  lead FED

Principal Investigators

• W. Curt LaFrance, Jr., MD, MPH · Providence VA Medical Center

• Jerzy Szarflarski, MD · University of Alabama at Birmingham

Study Design

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2017-09-15

Primary Completion

2022-05-15

Completion

2022-09-14

Countries

• United States

Study Locations