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EEG-fMRI: Towards a Useful Clinical Tool in Epilepsy

NCT02410889 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 29

Last updated 2016-10-12

No results posted yet for this study

Summary

The purpose of this project is to develop the method of combined recording of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) in order to improve understanding of the relationship between electrical (EEG) and blood flow (fMRI) responses to epileptic discharges as a necessary step towards clinical use. One factor that currently limits the use of EEG-fMRI in patients with epilepsy is that a relatively large proportion of patients do not show any fMRI response despite epileptic activity having been detected on the EEG recorded during scanning. The reasons for this are unclear, which makes it difficult to predict in advance whether useful information will be gained from the scanning session. What is it about some epileptic discharges that results in a detectable change in the fMRI signal, while others which are no less obvious or frequent do not? This question will be addressed by determining the factors that are responsible for the occurrence of robust fMRI signal changes via detailed morphological, topographical and spectral analysis of the EEG signal on an event by event basis.

Conditions

Interventions

OTHER

EEG-fMRI scanning

Patients undergo EEG-fMRI scanning

Sponsors & Collaborators

  • University Hospital Birmingham

    collaborator OTHER

  • Birmingham and Solihull Mental Health NHS Foundation Trust

    collaborator OTHER

  • University of Birmingham

    lead OTHER

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-01-31
Primary Completion
2016-01-31
Completion
2016-01-31

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02410889 on ClinicalTrials.gov