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Predicting Cognitive and Emotional Health From Neurocircuitry Following TBI

NCT01803048 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 190

Last updated 2020-11-04

No results posted yet for this study

Summary

Abnormalities in structural and functional connectivity between brain regions have been suggested as putative biomarkers of mild traumatic brain injury (TBI) and significant contributors to neuropsychological functioning and injury outcome. The purpose of this study is to use two advanced magnetic resonance imaging (MRI) techniques called diffusion-weighted imaging (DWI) and resting state functional MRI to compare structural and functional connectivity between individuals with documented mild TBI and healthy controls. To evaluate the significance of structural and functional connectivity for behavior, the brain imaging data will then be related to measures of cognition and emotion. Over a 4-year period, 150 adults with documented mild TBI and 30 healthy controls will participate in the study.

The study will investigate the following questions and hypotheses:

1. Evaluate the DWI metric fractional anisotropy (FA) as a measure of white matter integrity across multiple stages of recovery following mild TBI relative to healthy controls. It is hypothesized that mild TBI will be associated with greater white matter abnormalities than healthy controls.
2. It is hypothesized that there will be a relationship between FA, cognition and emotion as a function of the injury.
3. It is hypothesized that functional connectivity will be related to FA.

Conditions

Sponsors & Collaborators

  • United States Department of Defense

    collaborator FED

  • University of Arizona

    lead OTHER

Principal Investigators

  • William D Killgore, Ph.D. · University of Arizona Psychiatry Department

Eligibility

Min Age
20 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-02-28
Primary Completion
2019-12-31
Completion
2019-12-31

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01803048 on ClinicalTrials.gov