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An Examination of Cognitive and Sensorimotor Processes in Patients With Epilepsy

NCT00859794 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 450

Last updated 2024-02-01

No results posted yet for this study

Summary

The overall goal of this project is to better understand the micro-physiology of human epilepsy and cognition using the intracranial electroencephalogram (iEEG), electrical brain stimulation, functional magnetic resonance imaging (fMRI), and histology.

Conditions

Interventions

OTHER

fMRI

Subjects will perform cognitive tasks during MRI scanning sessions to gather data about cognitive functions.

OTHER

Neuropsychological Testing

Subjects will have a neuropsych evaluation as part of their standard of care for surgery. The research team is asking the subject to release their neuropsychological evaluations for analysis.

OTHER

Additional electrode implantation

Subjects will typically have between 100-300 electrodes implanted as part of their surgery. Additional electrodes will be implanted that are able to record from smaller, more specific parts of the brain. This will allow for better understanding of how the brain is wired.

OTHER

Electrical brain stimulation

Intracranial or extracranial electrodes will be used to deliver electrical brain stimulation (amplitude 0.5-8.0mA) or sham stimulation of between 0.4 and 3000 milliseconds during cognitive task periods.

Sponsors & Collaborators

  • Northwell Health

    lead OTHER

Principal Investigators

  • Ashesh Mehta, M.D., Ph.D. · Zucker School of Medicine at Hofstra/Northwell and Feinstein Institute for Medical Research

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
5 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-11-30
Primary Completion
2029-02-28
Completion
2029-02-28

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00859794 on ClinicalTrials.gov