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The Interaction Between Oxytocin and Serotonin

NCT03426176 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2018-02-08

No results posted yet for this study

Summary

the study aims to explore whether there is an interaction between oxytocin and serotonin in the regulation of emotion-based behavior by using a between-subject randomized double blind pharmacological fMRI design during which 4 groups of healthy male subjects will receive combinations of oxytocin nasal-spray (versus placebo) and acute tryptophan depletion (ATD, versus placebo)

Conditions

  • Healthy

Interventions

DRUG

oxytocin nasal spray

intranasal administration of oxytocin (24 IU)

DRUG

intranasal placebo treatment (placebo-control for oxytocin)

intranasal administration of placebo nasal spray

DRUG

ATD treatment

oral administration of ATD (75.2g) (Acute Tryptophan Depletion)

DRUG

oral placebo treatment (placebo-control for ATD)

oral administration of a tryptophan-balanced mixture (78.2g)

Sponsors & Collaborators

  • University of Electronic Science and Technology of China

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-02-01
Primary Completion
2019-06-15
Completion
2019-07-15

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03426176 on ClinicalTrials.gov