MedTrace Logo

Effects of Ketamine on Eye Movements, Perception and Brain Function

NCT02701933 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2016-03-08

No results posted yet for this study

Summary

In this study, the investigators examine the effects of low-dose ketamine on different oculomotor, perceptual and cognitive functions. They also examine effects on concurrent brain activity using blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI). A sample of N=25 healthy, male participants is required to complete the study. The design is within-subjects, placebo-controlled, double-blind and cross-over. A targeted ketamine level in plasma of 100ng/ml is applied. It is hypothesised that ketamine, compared to placebo, will lead to changes in task performance and brain activity similar to those observed in patients with schizophrenia.

Conditions

  • Functional Neuroimaging

Interventions

DRUG

Ketamine

Racemic ketamine, intravenous, at a concentration of 10mg ketamine per 50ml infusion

DRUG

Saline

Saline, intravenous infusion

Sponsors & Collaborators

  • University of Bonn

    lead OTHER

Principal Investigators

  • Ulrich Ettinger, PhD · Department of Psychology, University of Bonn

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-04-30
Primary Completion
2014-12-31
Completion
2014-12-31

Countries

  • Germany

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02701933 on ClinicalTrials.gov