Intracranial Artery Stenosis Magnetic Resonance Imaging: Aetiology and Progression

Summary

Stroke has become the leading cause of death in China. It has been shown that intracranial artery stenosis (ICAS) plays a key role in Chinese stroke patients. Although most of stenotic diseases in intracranial arteries are atherosclerotic, a substantial number of other vascular diseases, such as dissection, arteritis, moyamoya disease, and reversible cerebral vasoconstriction syndrome (RCVS), can also lead to intracranial artery luminal narrowing. It is challenging to differentiate the etiologies of ICAS relying on measuring luminal narrowing by angiographical approaches. In addition, the progression of intracranial atherosclerotic disease (ICAD) has been demonstrated to be highly associated with the risk of ischemic cerebrovascular events. However, the influence factors for ICAD progression remains unclear.

High-resolution magnetic resonance imaging (HR-MRI) has been widely used to assess ICAS diseases. The different etiologies of ICAS are differentiable by MR-MRI according to the features of location, shape, signal pattern, remodeling, and contrast enhancement. Investigators have proved that HR-MRI is a reproducible technique that may be reliably utilized to monitor the changes of ICAD during natural follow-up or medical treatment.

The ICASMAP (Intracranial Artery Stenosis MR Imaging: Aetiology and Progression) is a prospective, cross-sectional, observational, and multicenter study. The objectives of ICASMAP are to determine: 1) the spectrum of etiology of ICAS in stroke patients; and 2) the influence factors for progression of ICAD. A total of 300 patients with symptomatic stenotic disease in intracranial arteries (stenosis range: 30%-99%) will be recruited within two weeks after symptom onset from 18 different hospitals across Beijing-Tianjin-Hebei region in China within 1 year. All the patients will undergo HR-MRI for intracranial arteries at baseline, one-year, and two-years. The clinical risk factors will be collected and blood draw will be conducted. The ICASMAP study may help to improve the precise diagnosis and intervention of ICAS and stroke prevention.

Conditions

• Ischemic Stroke
• Transient Ischemic Attack
• Intracranial Artery Stenosis

Sponsors & Collaborators

• Xuanwu Hospital, Beijing

  collaborator OTHER

• Beijing Tiantan Hospital

  collaborator OTHER

• Beijing Hospital

  collaborator OTHER_GOV

• 309th Hospital of Chinese People's Liberation Army

  collaborator OTHER

• Navy General Hospital, Beijing

  collaborator OTHER

• First Hospitals affiliated to the China PLA General Hospital

  collaborator OTHER_GOV

• Beijing Huairou Hospital

  collaborator OTHER

• Beijing Pinggu District Hospital

  collaborator OTHER

• Beijing Shuyi Hospital

  collaborator OTHER

• Tianjin First Central Hospital

  collaborator OTHER

• Tianjin 4th Centre Hospital

  collaborator UNKNOWN

• Tianjin Union Medical Center

  collaborator OTHER

• Hebei Medical University Third Hospital

  collaborator OTHER

• Affiliated Hospital of Chengde Medical University

  collaborator OTHER

• Tangshan Gongren Hospital

  collaborator OTHER

• The First Affiliated Hospital of Hebei North University

  collaborator OTHER

• Cangzhou People's Hospital

  collaborator OTHER

• Harrison International Peace Hospital

  collaborator OTHER

• Tsinghua University

  lead OTHER

Principal Investigators

• Xihai Zhao, MD, PhD · Tsinghua University

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-10-14

Primary Completion

2021-03-25

Completion

2022-03-25

Countries

• China

Study Locations