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Mast Cell Activation Test in Allergic Disease

NCT03406325 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 19

Last updated 2020-04-09

Study results available
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Summary

Activation of mast cells in the immune system is known to cause allergic reactions sometimes with severe systemic symptoms. The investigators have recently developed a blood-based mast cell activation diagnostic test in which levels of functional activation in-vitro in primary cultured mast cells generated from the peripheral blood of single individuals can be assessed. It is the hypothesis that the test can be used to predict the potential state of in-vivo mast cell activation in any individual based on the functional activation profiles exhibited by their cultured mast cells. The investigators now wish to translate their in-vitro findings in a pilot study to disease groups where mast cell activation is expected to be high. These include highly allergic individuals; those with chronic idiopathic urticaria; those with mastocytosis; and those with the mast cell activation syndrome. Furthermore, they will use the functional genomics approach to identify gene expression biomarkers that are correlated with such diseases. The results will be compared with data that have been collected from a cohort of healthy control blood donors.

Conditions

Sponsors & Collaborators

  • Chinese University of Hong Kong

    collaborator OTHER

  • Stanford University

    collaborator OTHER

  • Hong Kong Sanatorium & Hospital

    lead INDUSTRY

Principal Investigators

  • Tak H Lee · Hong Kong Sanatorium and Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-02-01
Primary Completion
2019-12-01
Completion
2019-12-01

Countries

  • Hong Kong

Study Locations

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Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03406325 on ClinicalTrials.gov