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Periodontal Debridement Associated With Systemic Antibiotics and Single/Repeated PDT to Treat Aggressive Periodontitis

NCT03132714 · Status: COMPLETED · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 46

Last updated 2017-04-28

No results posted yet for this study

Summary

The aim of this project is to compare the efficacy and the local effect of the association of single or repeated application of photodynamic therapy (PDT) with antibiotic agents using Amoxicillin + Metronidazole or Clarithromycin in the treatment of patients with Generalized Aggressive Periodontitis (GAgP).

Conditions

  • Aggressive Periodontitis, Generalized

Interventions

PROCEDURE

Full-mouth ultrasonic debridement

Full-mouth ultrasonic debridement will be performed in order to treat diseased sites

DRUG

Amoxicillin 500mg

Administration of Amoxicillin 500mg tid for 7 days

DRUG

Metronidazole 400mg

Administration of Metronidazole 400mg tid for 7 days.

DRUG

Clarithromycin 500mg

Administration of Clarithromycin 500mg bid for 7 days

PROCEDURE

Single application of PDT

Single application of photodynamic therapy (PDT) at day 0.

PROCEDURE

Repeated application of PDT

Repeated application of photodynamic therapy (PDT) at 0, 1, 2, 7 and 14 days post-operatively.

Sponsors & Collaborators

  • Universidade Estadual Paulista Júlio de Mesquita Filho

    lead OTHER

Principal Investigators

  • Mauro P Santamaria, DDS, PhD · Universidade Estadual Paulista Júlio de Mesquita Filho

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-03-31
Primary Completion
2016-10-31
Completion
2016-10-31

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03132714 on ClinicalTrials.gov