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Efficacy of Azithromycin as an Adjunct to Non-Surgical Periodontal Treatment

NCT03629288 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2022-09-09

No results posted yet for this study

Summary

This study evaluates the effect of the systemic administration of azithromycin as a therapy associated with non-surgical periodontal treatment, in the clinical and microbiological variables of patients with Severe Periodontitis with moderate rate of progression (Stage III grade B). A double-blind, randomized, controlled trial was conducted with 18 voluntary patients with a history of moderate to severe chronic periodontitis, who met the inclusion and exclusion criteria and signed an informed consent.

The intervention group received non-surgical periodontal therapy (NSPT) plus azithromycin, and the control group received NSPT plus placebo. Probing Pocket Depth (PPD) Clinical Attachment Level (CAL),O'Leary index (OI) and Bleeding on Probing (BoP) were evaluated as clinical variables while Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf), Treponema denticola (Td), Fusobacterium nucleatum (Fn) were the microbiological variables detected by conventional Polymerase chain reaction (PCR).

Conditions

  • Periodontitis

Interventions

OTHER

Lactose tab

Tablet containing lactose Procedure: Periodontal treatment Scaling and root planning

DRUG

Azithromycin

Tablet containing 500mg Azithromicyn. Procedure: Periodontal treatment Scaling and root planning

Sponsors & Collaborators

  • Universidad Nacional Andres Bello

    lead OTHER

Principal Investigators

  • Mariely A Navarrete, MSc · Universidad Nacional Andres Bello

  • Mariely A Navarrete, MSc · Universidad Nacional Andres Bello

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
35 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-03-01
Primary Completion
2016-09-02
Completion
2016-10-30

Countries

  • Chile

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03629288 on ClinicalTrials.gov