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Renal Transplant Injury and the Renin-Angiotensin System in Kids (RETASK)

NCT03317925 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 29

Last updated 2017-11-08

No results posted yet for this study

Summary

In pediatric kidney transplant patients, rejection, medication toxicity and ischemia cause early and chronic renal allograft injury, which reduces graft lifespan and patient survival. Early detection of injury would facilitate prevention and treatment. The gold standard surveillance biopsy has limitations including delayed discovery of injury. No noninvasive test identifies graft injury before it is clinically apparent. This project's goal is to develop a novel early marker of subclinical graft injury to facilitate prompt recognition and treatment.

Conditions

  • Renal Transplant
  • Renin-Angiotensin System
  • Rejection Acute Renal
  • Rejection Chronic Renal
  • Rejection of Renal Transplant

Interventions

PROCEDURE

Renal Transplantation

Kidney transplantation and biomarkers that can identify injury after transplant.

Sponsors & Collaborators

Principal Investigators

  • Andrew M South, MD MS · Wake Forest University Health Sciences

Eligibility

Min Age
1 Year
Max Age
20 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-07-16
Primary Completion
2016-01-20
Completion
2017-04-26

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03317925 on ClinicalTrials.gov