Context - Remote Ischemic Conditioning in Renal Transplantation - Effect on Immediate and Extended Kidney Graft Function

Summary

The purpose of this study is to determine whether remote ischemic conditioning can improve the outcome after renal transplantation with deceased donor. Remote ischemic conditioning is performed on the patient receiving a kidney from a deceased donor. Remote ischemic conditioning is done during the operation by inflating a tourniquet on the patients leg before opening the blood circulation to the kidney. The study focus on both the immediate kidney function after the transplantation, but also on the extended kidney function one year after the transplantation.

Conditions

• Kidney Transplantation
• Delayed Graft Function
• Acute Kidney Injury
• Glomerular Filtration Rate

Interventions

OTHER

Remote ischemic conditioning

Patients receiving kidney transplantation from a deceased donor. Remote ischemic conditioning (rIC) is done by inflating a tourniquet (250mmHg) on the patients leg before reperfusion of the kidney. The tourniquet stays on the leg on the opposite site of were the kidney is placed. rIC is done 4 x 5 min with 5 min intervals between with free blood flow.

Sponsors & Collaborators

• Sahlgrenska University Hospital

  collaborator OTHER

• Lundbeck Foundation

  collaborator OTHER

• Novo Nordisk A/S

  collaborator INDUSTRY

• AP Moeller Foundation

  collaborator OTHER

• Danish Society of Nephrology

  collaborator OTHER

• Aarhus University Hospital

  collaborator OTHER

• Erasmus Medical Center

  collaborator OTHER

• University Medical Center Groningen

  collaborator OTHER

• Danish Council for Independent Research

  collaborator OTHER

• University of Aarhus

  lead OTHER

Principal Investigators

• Nicoline V Krogstrup, MD · Klinisk Institut, Aarhus University

• Bente Jespersen, Professor, DMSc, MD · Klinisk Institut, Aarhus University

• Henrik Birn, DMSc, MD · University of Aarhus

• Mihai Oltean, MD, PhD · Sahlgrenska University Hospital

• Gertrude J. Nieuwenhuijs-Moeke, MD · University Medical Center Groningen

• Frank J. M. F. Dor, MD, PhD · Erasmus Medical Center

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2011-06-30

Primary Completion

2015-06-30

Completion

2016-06-30

Countries

• Denmark
• Netherlands
• Sweden

Study Locations