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Negative-Positive Valence Domains in Anxiety and Depression

NCT03310398 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 248

Last updated 2017-10-16

No results posted yet for this study

Summary

Anxiety and depression are highly prevalent and disabling conditions that frequently co-occur, and are costly to the individual and society. Despite important advances in our understanding of these disorders, there is a significant unmet need to identify reliable and clinically useful tests that can predict prognosis, inform treatment choice for a given individual, and improve treatment outcomes. The aim of this project is to fill this critical gap by validating a battery of measures including brain imaging, psychophysiology, behavior, and self-report that will reliably assess positive and negative affect, or valence, system functioning in a broad sample of individuals screened for anxiety and depression as part of their routine primary care visits.

Conditions

Interventions

BEHAVIORAL

NeuroImaging

standard anatomical and functional imaging

BEHAVIORAL

Psychophysiological

Hear rate, Vagal Tone, Skin Conductance, and Startle Reflex Electromyogram

Sponsors & Collaborators

Principal Investigators

  • Martin P Paulus, MD · UC San Diego

  • Murray B Stein, MD, MPH · UC San Diego

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-09-01
Primary Completion
2017-04-30
Completion
2017-06-30

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03310398 on ClinicalTrials.gov