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iFR Guided Multi-vessel Revascularization During Percutaneous Coronary Intervention for Acute Myocardial Infarction

NCT03298659 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1146

Last updated 2025-04-04

No results posted yet for this study

Summary

In patients with acute ST-elevation myocardial infarction (STEMI), 40-60% have multi-vessel disease with an increased cardiovascular morbidity and mortality. Although it is not recommended to revascularize noninfarct lesions during the acute intervention, recent investigations suggest the opposite and show improved outcome after direct revascularization of noninfarct lesions. It is undesirable to risk procedure-related complications by treating noninfarct lesions without impaired flow. It is currently unknown whether pressure guided revascularization of noninfarct lesions in the acute phase improves outcome compared to the current guidelines.

The iMODERN trial aims to compare an iFR-guided intervention of noninfarct lesions during the acute intervention with a deferred stress perfusion CMR-guided strategy during the outpatient follow-up, to determine the optimal therapeutic approach for STEMI patients with multivessel lesions.

Conditions

  • Acute Myocardial Infarction
  • Multi Vessel Coronary Artery Disease

Interventions

DIAGNOSTIC_TEST

iFR

Treatment guided by instantaneous wave-free ratio

DIAGNOSTIC_TEST

CMR

Treatment guided by stress perfusion CMR

Sponsors & Collaborators

  • Volcano Europe BVBA/SPRL

    collaborator UNKNOWN

  • Biotronik AG

    collaborator INDUSTRY

  • Stichting Life Sciences & Health

    collaborator UNKNOWN

  • Duke Cardiovascular Magnetic Resonance Center

    collaborator UNKNOWN

  • Radboud University Medical Center

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-12-21
Primary Completion
2025-05-31
Completion
2027-05-31

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03298659 on ClinicalTrials.gov