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Phages Dynamics and Influences During Human Gut Microbiome Establishment

NCT03296631 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 19

Last updated 2019-07-16

No results posted yet for this study

Summary

Microbial communities are key components of human environment. Consequently, human gut microbiome have been extensively studied providing a better understanding of the relations between bacterial populations and host physiology. However, a typical analysis tends to elude the complexity of the mixes in term of species, strains, as well as extra-chromosomal DNA molecules such as and phages. MetaKids project aims at bringing, at an unprecedented resolution, a new view of those populations and the internal relationships during human gut establishment, a crucial step with long-term impacts on host health. This project relies on the ability of Meta3C, a newly technique developed in the lab, to identify the bacterial host genomes of the different phages the investigators will detect thanks to the physical collision these molecules experience. Given the role that human gut phages may play in shaping the development of host microbiomes, their potential for application is of great interest.

Conditions

  • Human Gut Microbiome Development

Interventions

OTHER

collection of diapers with fresh stools

collection of diapers with fresh stools

Sponsors & Collaborators

  • City of Orsay

    collaborator UNKNOWN

  • Institut Pasteur

    lead INDUSTRY

Principal Investigators

  • Martial Marbouty · Institut Pasteur / CNRS

Eligibility

Min Age
10 Weeks
Max Age
9 Months
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-09-05
Primary Completion
2018-12-31
Completion
2018-12-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03296631 on ClinicalTrials.gov