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Pathogen-microbiome Interaction During Helicobacter Pylori Infection

NCT05121025 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 180

Last updated 2024-12-05

No results posted yet for this study

Summary

Helicobacter pylori affects the gut microbiome in ways that are only partially understood. In which patients H. pylori causes severe disease and in whom it merely colonizes, possibly even with beneficial effects, is not understood. The investigators are pursuing the hypothesis that changes in the gut microbiome that can be easily measured in stool have such predictive value.

Conditions

  • Helicobacter Pylori Infection

Interventions

DIAGNOSTIC_TEST

Analysis of gut microbiome and immune signatures

The investigators will analyse the microbiome composition (16S rDNA-sequencing and metagenomics), microbiome activity (RNA-sequencing of stool bacteria and metabolite sampling) and immune cell activity (leukocyte RNA-sequencing) of all study groups.

Sponsors & Collaborators

  • University Hospital Freiburg

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-03-11
Primary Completion
2025-06-30
Completion
2025-12-30

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05121025 on ClinicalTrials.gov