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Vitamin D-related Genes and Metabolic Disorders

NCT03279432 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1021

Last updated 2017-09-12

No results posted yet for this study

Summary

The link between metabolic disturbances and vitamin D receptor (VDR) and MEGALIN (or LRP2) gene polymorphisms remains unclear, particularly among African-American adults. The associations of single nucleotide polymorphisms (SNPs) for VDR \[rs1544410(BsmI:G/A), rs7975232(ApaI:A/C), rs731236(TaqI:G/A)\] and MEGALIN \[rs3755166:G/A,rs2075252:C/T, rs2228171:C/T\] genes with incident and prevalent metabolic disturbances, including obesity, central obesity and metabolic syndrome (MetS) were evaluated.

From 1,024 African-Americans participating in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS, Baltimore, MD, 2004-2013) study, 539 subjects were selected who had complete genetic data as well as covariates selected for metabolic outcomes at two consecutive examinations (visits 1 and 2) with a mean follow-up time of 4.64±0.93y. Haplotype (HAP) analyses generated polymorphism groups that were linked to incident and prevalent metabolic disturbances.

Conditions

  • Metabolic Syndrome
  • Obesity
  • Central Obesity

Sponsors & Collaborators

  • National Institute on Aging (NIA)

    lead NIH

Principal Investigators

  • Alan B Zonderman, PhD · National Institute on Aging (NIA)

  • Michele K Evans, MD · National Institute on Aging (NIA)

Eligibility

Min Age
30 Years
Max Age
64 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2004-08-18
Primary Completion
2013-07-07
Completion
2013-07-07

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03279432 on ClinicalTrials.gov