Break It Up: A Study Evaluating Breaking Up Daily Sedentary Behavior in Youth

Summary

Background:

Some studies have found that people can better process sugars when they take walking breaks. Studies have also found that children's attention and memory may improve after exercise. It is not known if short walking breaks have the same effects. Researchers want to study if breaking up sitting with walking for 6 days helps children s bodies use sugars and improves concentration.

Objectives:

To learn if breaking up sedentary (low-activity) time with short walking breaks over 6 days affects how children s bodies use sugar. To learn if breaking up sedentary time changes children s attention, memory, feelings, activity, or eating.

Eligibility:

Children ages 7-11 in general good health

Design:

Participants will be screened with:

* Medical history
* Physical exam
* Fasting blood tests. On 2 out of 7 total study visits, participants cannot eat or drink after 10 p.m. the night before.
* Full-body X-ray
* EKG (Electronic signals that record heart function through stickers)
* Treadmill exercise. Heart, blood pressure, and oxygen will be monitored.
* Questions about the child s health, socialization, and activity, and parent s education and economic status
* Picture vocabulary test
* Dietician meeting (Questions about eating habits)

Participants will have visits on 6 consecutive days. Over that time, they will wear 2 devices to monitor blood sugar and activity (even while at home).

Participants will have 5 after-school visits. These include:

* Health check
* Snack plus food for the next 24 hours
* Activity monitored
* 3-hour sitting tests. Participants will do non-active things. Some will have 3-minute walks every 30 minutes.
* Cognitive tests and questions about mood and anxiety are given on days #1 \& 5.

Participants will fast before the last visit in the morning. They will have:

* 9 blood draws by IV catheter. Participants will drink sugar water.
* Sitting test
* Activity monitored
* Meal (food buffet)

Conditions

• Healthy
• Obesity
• Overweight

Interventions

OTHER

Walking Bouts

Six daily 3 hour sessions with prompted 3-minute moderate-intensity walking bouts performed on a treadmill every 30 minutes throughout the 3 hour duration. There will be a total of 6 walking bouts (18 minutes total) each day. Moderate-intensity walking speed and grade will be selected to achieve 80% of the heart rate achieved at the ventilatory threshold as determined during a V02max test.

OTHER

Sedentary

(Control 'intervention') Six daily 3 hour sessions with no physical activity (i.e. subject remains sedentary in seated or recumbent position) throughout the 3 hour duration.

Sponsors & Collaborators

• Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

  lead NIH

Principal Investigators

• Jack A Yanovski, M.D. · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

7 Years

Max Age

11 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-07-26

Primary Completion

2020-06-26

Completion

2021-02-23

Countries

• United States

Study Locations